Figure7_High_T2

Applications

Random Walk Imaging’s software protocols for advanced diffusion MRI have been used for various applications.

Find your area of interest and read more about what has been done in your field of research.

Applications

Random Walk Imaging’s software protocols for advanced diffusion MRI have been used for various applications.

Find your area of interest and read more about what has been done in your field of research.

Brain Tumors

Applying Random Walk Imaging’s software protocols in brain tumors has attracted significant interest. Brain tumor microstructure acquired with our protocols has been correlated to histopathology, which is the gold standard for diagnosis. Several ongoing studies on grading, follow-up of treatment and surgical planning have been presented at conferences.

Cardiac

Movement pose a great challenge for acquiring diffusion MRIs, and the beating of the heart has limited the use of these methods on this organ. However, using motion-compensated sequences when acquiring images, our software protocols for diffusion MRI has been successfully used for in-vivo imaging of the heart.

Clinical Implementation

Our software protocols for advanced diffusion MRI were initially developed for NMR microimaging systems. To transfer the methods from these systems, there has been numerous studies of the necessary adaptations for clinical scanners, including sequence optimization to reduce scan times, as well as ways to minimize artifacts.

Kidney

It has been shown that novel information of the kidney microstructure, not accessible by conventional diffusion encoding, can be probed in-vivo by the use of our software protocols for advanced diffusion MRI.

Multiple Sclerosis

Compared to conventional diffusion encoding methods, applying our diffusion MRI software protocols significantly improves the ability to capture white matter changes in subjects with Multiple Sclerosis. The observed changes have been correlated to clinical scores, and highlight this tool as a potentially complementary MRI modality to track disease progression and treatment response.

Neuroscience

Our software protocols for advanced diffusion MRI methods have been used in the brain to study its microstructure in more detail and both changes in white and gray matter have been investigated. Applying tractography to our methods improves outcomes in areas where identification of tracts has previously been difficult, such as at fiber crossings.

Breast Cancer

MDD can be applied to breast cancer patients providing both conventional ADC values, consistent with literature, and novel contrasts reporting on cell shapes and tissue composition.

This independent characterization of cell shapes and orientations in addition to cell density probed by conventional DW MRI has the potential to improve current diagnosis of breast cancer.

Epilepsy

Multidimensional diffusion MRI methods have been used to study epilepsy, revealing the underlying microstructural changes in malformations of cortical development. This underscores the potential of this tool to non-invasively explore previously unattainable underlying sources of epileptic seizures.

Prostate Cancer

MDD for prostate cancer, applied in a successful proof of concept study submitted to RSNA-2020 and XXX (Greta please check and add some text)