Random Walk Imaging

Publications

The proprietary technologies are discussed in the listed publications.

Peer-reviewed original articles

2019


  1. H. Lundell, M. Nilsson, T. B. Dyrby, G. J. M. Parker, P. L. Hubbard Cristinacce, F.-L. Zhou, D. Topgaard, and S. Lasič. Multidimensional diffusion MRI with spectrally modulated gradients reveals unprecedented microstructural detail. Sci Rep. 2019 June 21.
  2. F. Szczpankiewicz, C.-F. Westin, and M. Nilsson. Maxwell-compensated design of asymmetric gradient waveforms for tensor-valued diffusion encoding. Magn. Reson. Med. 2019 May 31.
  3. F. Szczepankiewicz, J. Sjölund, F. Ståhlberg, J. Lätt, and M. Nilsson. Tensor-valued diffusion encoding for diffusional variance decomposition (DIVIDE): Technical feasibility in clinical MRI systems. PLoS One. 2019 March 28.
  4. B. Lampinen, F. Szczepankiewicz, M. Novén, D. van Westen, O. Hansson, E. Englund, J. Mårtensson, C.-F. Westin, and M. Nilsson. Searching for the neurite density with diffusion MRI: Challenges for biophysical modeling. Hum Brain Mapp. 2019 February 25.
  5. D. Topgaard. Diffusion tensor distribution imaging. NMR Biomed. 2019 February 7.

2018


  1. L. Ning, M. Nilsson, S. Lasič, C.-F. Westin, and Y. Rathi. Cumulant expansions for measuring water exchange using diffusion MRI. J. Chem. Phys. 148, 074109 (2018).
  2. J. P. de Almeida Martins and D. Topgaard. Multidimensional correlation of nuclear relaxation rates and diffusion tensors for model-free investigations of heterogeneous anisotropic porous materials. Sci. Rep. 8, 2488 (2018).

2017


  1. M. Palmgren, M. Hernebring, S. Eriksson, K. Elbing, C. Geijer, S. Lasič, P. Dahl, J.S. Hansen, D. Topgaard, and K. Lindkvist-Petersson. Quantification of the Intracellular Life Time of Water Molecules to Measure Transport Rates of Human Aquaglyceroporins. J Membr Biol. 2017 September 15.
  2. S. Lasič, H. Lundell, D. Topgaard, and TB. Dyrby.Effects of imaging gradients in sequences with varying longitudinal storage time – Case of diffusion exchange imaging. Magn Reson Med. 2017 July 31.
  3. M. Nilsson, J. Larsson, D. Lundberg, F. Szczepankiewicz, T. Witzel, C.-F. Westin, K. Bryskhe, and D. Topgaard.Liquid crystal phantom for validation of microscopic diffusion anisotropy measurements on clinical MRI systems. Magn Reson Med. 2017 July 7.
  4. S. Eriksson, K. Elbing, O. Söderman, K. Lindkvist-Petersson, D. Topgaard, and S. Lasič. NMR quantification of diffusional exchange in cell suspensions with relaxation rate differences between intra and extracellular compartments. PLoS One. 2017 May 11.
  5. M. Nilsson, S.  Lasič, I. Drobnjak, D. Topgaard, and C.-F. Westin. Resolution limit of cylinder diameter estimation by diffusion MRI: The impact of gradient waveform and orientation dispersion. NMR Biomed. 2017 March 20.
  6. B. Lampinen, F.  Szczepankiewicz, J. Mårtensson, D. van Westen, P. C. Sundgren, and M. Nilsson. Neurite density imaging versus imaging of microscopic anisotropy in diffusion MRI: A model comparison using spherical tensor encoding. Neuroimage. 2017 February 15.

2016


  1. F. Szczepankiewicz, D. van Westen, E. Englund, C.-F. Westin, F. Ståhlberg, J. Lätt, P. C. Sundgren, and M. Nilsson. The link between diffusion MRI and tumor heterogeneity: Mapping cell eccentricity and density by diffusional variance decomposition (DIVIDE). Neuroimage. 2016 November 15.
  2. D. Topgaard. Director orientations in lyotropic liquid crystals: Diffusion MRI mapping of the Saupe order tensor. Phys. Chem. Chem. Phys. 2016 March 28.
  3. C.-F. Westin, H. Knutsson, O. Pasternak, F. Szczepankiewicz, E. Özarslan, D. van Westen, C. Mattisson, M. Bogren, L. O’Donnell, M. Kubicki, D. Topgaard, and M. Nilsson. Q-space trajectory imaging for multidimensional diffusion MRI of the human brain. Neuroimage. 2016 July 15.
  4. B. Lampinen, F. Szczepankiewicz, D. van Westen, E. Englund, P. C Sundgren, J. Lätt, F. Ståhlberg, and M. Nilsson. Optimal experimental design for filter exchange imaging: Apparent exchange rate measurements in the healthy brain and in intracranial tumors. Magn Reson Med. 2016 March 10.
  5. Lasič, S. Oredsson, S. C.Partridge, L. H. Saal, D. Topgaard, M. Nilsson, and K. Bryskhe. Apparent exchange rate (AXR) for breast cancer characterization. NMR Biomed. 2016 February 29.
  6. P. de Almeida Martins and D. Topgaard. Two-dimensional correlation of isotropic and directional diffusion using NMR. Phys. Rev. Lett. 2016 February 23.
  7. Ahlgren, L. Knutsson, R. Wirestam, M. Nilsson, F. Ståhlberg, D. Topgaard, and S. Lasič. Quantification of microcirculatory parameters by joint analysis of flow-compensated and non-flow-compensated intravoxel incoherent motion (IVIM) data. NMR Biomed. 2016 March 8.

2015


  1. J. Sjölund, F. Szczepankiewicz, M. Nilsson, D. Topgaard, C.-F. Westin, and H. Knutsson. Constrained optimization of gradient waveforms for generalized diffusion encoding. J. Magn. Reson. 2015 December.
  2. M. Nilsson, F. Szczepankiewicz, D. van Westen, and O. Hansson. Extrapolation-based references improve motion and eddy-current correction of high b-value DWI data: Application in Parkinson’s disease dementia. PLoS One. 2015 November 3.
  3. D. Topgaard. Isotropic diffusion weighting using a triple-stimulated echo pulse sequence with bipolar gradient pulse pairs. Microporous Mesoporous Mater. 2015 March 15.
  4. S. Eriksson, S. Lasič, M. Nilsson, C.-F. Westin, and D. Topgaard. NMR diffusion encoding with axial symmetry and variable anisotropy: Distinguishing between prolate and oblate microscopic diffusion tensors with unknown orientation distribution. J. Chem. Phys. 2015 March 9.
  5. F. Szczepankiewicz, S. Lasič, D. van Westen, P. C. Sundgren, E. Englund, C.-F. Westin, F. Ståhlberg, J. Lätt, D. Topgaard, and M. Nilsson. Quantification of microscopic diffusion anisotropy disentangles effects of orientation dispersion from microstructure: Applications in healthy volunteers and in brain tumors. NeuroImage. 2015 January 1.

2014


  1. S. Lasič, F. Szczepankiewicz, S. Eriksson, M. Nilsson, and D. Topgaard. Microanisotropy imaging: quantification of microscopic diffusion anisotropy and orientational order parameter by diffusion MRI with magic-angle spinning of the q-vector. Front. Physics. 2014 February 27.

2013


  1. D. Topgaard. Isotropic diffusion weighting in PGSE NMR: Numerical optimization of the q-MAS PGSE sequence. Microporous Mesoporous Mater. 2013 September 15.
  2. M. Nilsson, J. Lätt, D. van Westen, S. Brockstedt, S. Lasič, F. Ståhlberg, and D. Topgaard. Noninvasive mapping of water diffusional exchange in the human brain using filter-exchange imaging. Magn. Reson. Med. 2013 July 26.
  3. S. Eriksson, S. Lasič, and D. Topgaard. Isotropic diffusion weighting in PGSE NMR by magic-angle spinning of the q-vector. J. Magn. Reson. 2013 January.

2011


  1. S. Lasič, M. Nilsson, J. Lätt, F. Ståhlberg, and D. Topgaard. Apparent exchange rate (AXR) mapping with diffusion MRI. Magn. Reson. Med. 2011 March 28.

2009


  1. I. Åslund, A. Nowacka, M. Nilsson, and D. Topgaard. Filter-exchange PGSE NMR determination of cell membrane permeability. J. Magn. Reson. 2009 October.

Book chapters & reviews

  1. D. Topgaard. Multidimensional diffusion MRI. J. Magn. Reson. 275, 98-113 (2017).
  2. D. Topgaard. NMR methods for studying microscopic diffusion anisotropy. Diffusion NMR of Confined Systems: Fluid transport in porous solids and heterogeneous materials, 226-259 (2016), Royal Society of Chemistry, Cambridge, UK.
  3. N. Shemesh, S. N. Jespersen, D. C. Alexander, Y. Cohen, I. Drobnjak, T. B. Dyrby, J. Finsterbusch, M. A. Koch, T. Kuder, F. Laun, M. Lawrenz, H. Lundell, P. P. Mitra, M. Nilsson, E. Özarslan, D. Topgaard, and C.-F. Westin. Conventions and nomenclature for double diffusion encoding (DDE) NMR and MRI. Magn. Reson. Med. 75, 82-87 (2015).
  4. C.-F. Westin, F. Szczepankiewicz, O. Pasternak, E. Özarslan, D. Topgaard, H. Knutsson, and M. Nilsson. Measurement tensors in diffusion MRI: Generalizing the concept of diffusion encoding. Med Image Comput Comput Assist Interv 8675:209–216 (2014).
  5. D. Bernin and D. Topgaard. NMR diffusion and relaxation correlation methods: New insights in heterogeneous materials. Curr. Opin. Colloid Interface Sci. 18, 166-172 (2013).

Theses

  1. Filip Szczepankiewicz. Imaging diffusional variance by MRI: The role of tensor-valued diffusion encoding and tissue heterogeneity. Dept. of Medical Radiation Physics, Lund University, Nov 2016.
  2. Stefanie Eriksson. Development of novel diffusion NMR methods : Preclinical applications in colloidal model systems. Dept. of Physical Chemistry, Lund University, May 2016.
  3. Markus Nilsson. Biophysical modelling in diffusion MRI: The role of tissue microstructure and water exchange. Dept. of Medical Radiation Physics, Lund University, October 2011.
  4. Ingrid Åslund. Measuring Material Properties through Gradient Based NMR: Diffusion and Imaging. Dept. of Physical Chemistry, Lund University, September 2010.