Our collaborators, Björn Lampinen et al., have published an interesting article in NeuroImage, where our Research Partner Dr. Markus Nilsson is senior author. This paper discusses how conventional diffusion MRI entangles information on the microscopic scale, and how this can result in parameter bias.
Data acquired from healthy volunteers and glioma patients in this article pinpoint the drawbacks of relying on model assumptions; they will never be as specific as obtaining measurements that separate information on tissue architecture already at the acquisition stage without the need of biophysical models.