Random Walk Imaging


RWI methods are implemented on several different Philips MRI scanners, studying healthy brain, tissue permeability, multiple sclerosis, epilepsy, as well as tumors in brain and breast. Scanner information is detailed below.

Our methods to map cell structure and exchange have been implemented on the Philips Achieva platform (3 T, 80 mT/m), and used to investigate brain and breast pathologies.The cell structure method has also been implemented on the Philips Achieva (7 T, 60 mT/m) to study brain pathologies.

Do you wish to implement our methods? Please visit software and methods.

Photo: Philips Health Systems

Projects performed on the Philips Platform

Multiple sclerosis project

Our colleague Dr. Samo Lasič, together with collaborators in Hvidovre, Denmark, run an ongoing study investigating whether our MRI methods are able to differentiate between MS-related pathologies in focal lesions, as well as in normal appearing white matter. They are also evaluating the diagnostic value of these new MRI methods, to prepare for implementation in […]

Characterization of Epileptogenic Lesions by 7T MRI

This project aims to explore how well 7 T diffusion MRI performs in characterizing epileptogenic lesions. Methods developed by Random Walk Imaging are added to an existing protocol, and the wish is to compare data to histology from excised tissue. Scan time is 7 minutes and is performed on a Philips Achieva (7 T, 60 […]

The link between tissue heterogeneity and diffusional variance can aid in distinguishing between aggressive and less aggressive brain tumors

Non-invasive brain tumor differentiation

In this article, our method to measure structure is used to non-invasively separate highly aggressive brain tumors from less aggressive ones. Microstructure of tumor tissue can be examined non-invasively using MRI. However, it is not well-established how differences in MRI measurements are coupled to tissue microstructure. To investigate how these two are linked, the following […]

Breast cancer differentation with the RWI exchange method

In this publication, different breast cancer subtypes are distinguished using our exchange method. Although MRI has shown promise for the characterization of breast cancer, it has low specificity to malignant subtypes. Here, the ability of our exchange method was tested, and shown to be able to distinguish different types of breast cancer cells. Furthermore, the […]